St. Louis, Missouri is the second-largest city in Missouri, . It is located on the eastern border of the state, near the confluence of the Mississippi and the Missouri Rivers. As of 2020, the city proper had a population of around 301,500, while the bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million, making it the largest metropolitan area in Missouri, the second-largest in Illinois, and the 20th-largest in the United States.
St. Louis became part of the United States due to the Louisiana Purchase; the city was then the point of embarkation for the Corps of Discovery on the Lewis and Clark Expedition. In the 19th century, St. Louis became a major port on the Mississippi River. From the 1870 census until the 1920 census, it was counted as the fourth-largest city in the country. It separated from St. Louis County in 1877, becoming an independent city and limiting its own political boundaries.
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- see also: Advocacy/United States/Central